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Richard C Hartley Selected Research

malonic acid (malonate)

1/2022Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
1/2020Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury.

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Richard C Hartley Research Topics

Disease

7Reperfusion Injury
01/2022 - 06/2013
5Neoplasms (Cancer)
01/2021 - 11/2002
5Mitochondrial Diseases (Mitochondrial Disease)
12/2018 - 07/2009
3Myocardial Infarction
01/2022 - 06/2013
3Stroke (Strokes)
01/2018 - 06/2013
2Hypertension (High Blood Pressure)
01/2022 - 01/2018
2Ischemia
01/2022 - 01/2020
2Metabolic Diseases (Metabolic Disease)
11/2021 - 12/2018
2Type 2 Diabetes Mellitus (MODY)
11/2021 - 07/2009
2Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 01/2015
2Hypoxia (Hypoxemia)
01/2020 - 06/2012
1Fatty Liver
11/2021
1Hypertriglyceridemia
11/2021
1Diabetic Nephropathies (Diabetic Nephropathy)
04/2021
1Fibrosis (Cirrhosis)
04/2021
1Albuminuria
04/2021
1Adenocarcinoma
01/2020
1Diabetic Cardiomyopathies
12/2019
1Cardiomyopathies (Cardiomyopathy)
12/2019
1Hemochromatosis (Bronze Diabetes)
01/2019
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2019
1Heart Failure
12/2018
1Infections
12/2018
1Insulin Resistance
11/2018
1Cataract (Cataracts)
10/2018
1Inflammation (Inflammations)
01/2018
1Virus Diseases (Viral Diseases)
11/2016
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
11/2016
1Hyperglycemia
02/2014
1Infarction (Infarctions)
06/2013
1Cognitive Dysfunction
10/2012
1Body Weight (Weight, Body)
12/2008
1Colonic Diseases
07/2005
1Atherosclerosis
03/2003
1Heart Diseases (Heart Disease)
11/2002

Drug/Important Bio-Agent (IBA)

8Reactive Oxygen Species (Oxygen Radicals)IBA
01/2022 - 07/2009
4Succinic Acid (Succinate)IBA
01/2022 - 11/2014
4Proteins (Proteins, Gene)FDA Link
11/2018 - 02/2014
3Succinate Dehydrogenase (Fumarate Reductase)IBA
01/2022 - 11/2014
3Pyruvaldehyde (Methylglyoxal)IBA
04/2021 - 02/2014
3Superoxides (Superoxide)IBA
01/2020 - 11/2018
2ProdrugsIBA
01/2022 - 01/2020
2malonic acid (malonate)IBA
01/2022 - 01/2020
2EstersIBA
01/2022 - 01/2020
2EnzymesIBA
11/2021 - 01/2020
2Glucose (Dextrose)FDA LinkGeneric
11/2021 - 11/2018
2MitoGamideIBA
04/2021 - 12/2019
2Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2021 - 01/2015
2Oxidants (Oxidizing Agents)IBA
01/2020 - 11/2018
2AntioxidantsIBA
01/2019 - 03/2003
2Interferon Type IIBA
01/2018 - 11/2016
2QuercetinIBA
12/2008 - 07/2005
23-hydroxyflavoneIBA
12/2008 - 11/2002
1Thiosulfate Sulfurtransferase (Rhodanese)IBA
11/2021
1Sulfides (Thioethers)IBA
11/2021
1methyl malonateIBA
01/2020
1Transcription Factors (Transcription Factor)IBA
01/2019
1IronIBA
01/2019
1Peptide Hormones (Polypeptide Hormones)IBA
01/2019
1HepcidinsIBA
01/2019
1Mitochondrial Proteins (Mitochondrial Protein)IBA
12/2018
1Mitochondrial DNA (mtDNA)IBA
12/2018
1Insulin (Novolin)FDA Link
11/2018
1ParaquatIBA
11/2018
1AMP-Activated Protein KinasesIBA
11/2018
1Phenylephrine (Neo-Synephrine)FDA LinkGeneric
10/2018
1NADPH Oxidases (NAD(P)H oxidase)IBA
01/2018
14-phenylbutyric acid (Buphenyl)FDA Link
01/2018
1ProteomeIBA
01/2018
1Protein Isoforms (Isoforms)IBA
01/2018
1itaconic acidIBA
01/2018
1Antiviral Agents (Antivirals)IBA
11/2016
1Tretinoin (Retinoic Acid)FDA LinkGeneric
11/2016
1Nucleic AcidsIBA
02/2014
1Glyoxal (Ethanedial)IBA
02/2014
1Nitric Oxide DonorsIBA
06/2013
1Cysteine (L-Cysteine)FDA Link
06/2013
1Pharmaceutical PreparationsIBA
05/2013
1Adenosine (Adenocard)FDA LinkGeneric
10/2012
1Biological ProductsIBA
06/2012
1Adenosine Triphosphate (ATP)IBA
06/2012
1CalciumIBA
06/2012
1Oxygen (Dioxygen)IBA
06/2012
1AcidsIBA
12/2008
1GlucosidesIBA
12/2008
1FlavonoidsIBA
03/2003

Therapy/Procedure

1Organ Transplantation
01/2019
1Therapeutics
12/2018